Perinatal reference intervals for plasma homocysteine and factors influencing its concentration.

Cardiac troponin T alterations in myocardium and serum of rats after stressful, prolonged intense exercise. post-race antimyosin myocardial scintigraphy in asymptomatic marathon runners with elevated serum creatine kinase MB isoenzyme and troponin T levels. Plasma levels of cardiac troponin I after prolonged strenuous endurance exercise. Comparison of serum cardiac specific troponin-I with creatine kinase, creatine kinase-MB, tropomyosin, myoglobin, and C-reactive protein release in marathon runners: cardiac or skeletal muscle trauma. Characteristics of an albumin cobalt binding test for assessment of acute coronary syndrome patients: a multicenter study. Reduced albumin-cobalt binding with transient myocardial ischemia after elective percutaneous transluminal coronary angioplasty: a preliminary comparison to creatine kinase-MB, myoglobin, and troponin I. Iron status of active women and the effect of running a marathon on bowel function and gastrointestinal blood loss. Int Elevated cardiac troponin levels predict the risk of adverse outcome in patients with acute coronary syndromes. Academy of Clinical Biochemistry standards of laboratory practice: recommendations for the use of cardiac markers in coronary artery diseases. et al. ACC/AHA guidelines for the management of patients with unstable angina and non-ST segment elevation myocardial infarction. Moderately increased plasma total homocysteine (tHcy) concentrations have been associated with an increased risk of atherothrombotic vascular events (1). Disturbances in homocysteine metabolism have also been reported as a possible risk factor for early pregnancy loss and congenital birth defects, such as neural tube defects, as well as for maternal obstetric complications (2). Reference intervals for healthy maternal and newborn populations are scarce; in particular, we could not find data on large samples of women at delivery. Raijmakers et al. (3) reported tHcy results for samples collected at delivery or 4 h before caesarian section on 35 women. Bö hles et al. (4) and Malinow et al. (5) measured tHcy at delivery in 60 and 35 women, respectively, and Bjørke Monsen et al. (6) reported results for 169 samples collected between 96 to 108 h after birth. Available data on newborns include the results from one large study in Italy (7) and a few smaller studies (3– 6), among which only one is from North America; it included 35 women and their newborns (5). Mean tHcy values were quite different among these studies. Genetic, nutritional, and lifestyle factors are believed to influence tHcy concentrations (8, 9). Among the genetic factors, methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C gene polymorphisms are potentially important. Supplementation of the diet with folate …